Basic Knowledge of Fungal Biomarkers for the Diagnosis of Invasive Fugal Disease in Hematological Patients

DOI
  • Kimura Shun-ichi
    Division of Hematology, Jichi Medical University Saitama Medical Center

Bibliographic Information

Other Title
  • 血液領域の侵襲性真菌感染症診断における真菌バイオマーカーの基礎知識

Description

The diagnosis of invasive fungal disease relies fundamentally on culture tests. Culture tests and histopathological examinations are necessary for achieving a proven diagnosis. However, culture tests often lack sensitivity and can take considerable time to yield results, limiting their utility for monitoring and early diagnosis of invasive fungal disease. Therefore, non-culture-based tests, also known as biomarkers, become crucial. Fungal biomarkers that have been widely used in Japan include (1→3)-β-D-glucan (BDG), a pan-fungal (excluding Mucor and Cryptococcus) biomarker that detects the fungal cell wall component, and Aspergillus galactomannan antigen (GM), a component of the Aspergillus cell wall. The usefulness of novel biomarkers such as GM lateral flow assay and Aspergillus PCR for diagnosing invasive aspergillosis, as well as T2 Candida for diagnosing invasive candidiasis, has been reported overseas. This review summarizes the basic knowledge of fungal biomarkers for diagnosing invasive fungal disease in hematological patients, focusing on BDG and GM while touching upon novel biomarkers. The content of this review has been supplemented and revised based on Symposium 12, “Basic Knowledge of Biomarkers for the Diagnosis of Invasive Fungal Disease in Hematological Patients” at the 67th Annual Meeting of the Japanese Society for Medical Mycology held in October 2023.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390582850001459712
  • DOI
    10.11534/ishinkin.24.006
  • ISSN
    24345237
    24345229
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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