Noninvasive Transdermal Drug Delivery Technology for Biopharmaceuticals as an Alternative to Injection

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  • Goto Masahiro
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University Advanced Transdermal Drug Delivery System Center, Kyushu University
  • Tanaka Keisuke
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University
  • Toyofuku Kiyohiro
    Department of Applied Chemistry, Faculty of Engineering, Kyushu University

Bibliographic Information

Other Title
  • 注射に代わるバイオ医薬品の非侵襲的経皮薬物送達技術
  • –Breakthroughs by Membranous Approaches–
  • –膜学的アプローチによるブレークスルー–

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Description

The share of biopharmaceuticals is expected to further increase in the future. Biopharmaceuticals, which consist of peptides and proteins, are anticipated to exhibit greater specificity to target molecules within the body compared to small molecule drugs. However, most biopharmaceuticals are administered by injection because they are broken down by enzymes when taken orally. We have been exploring the development of transdermal formulations (e.g., patches or ointments) as an alternative to injectable biopharmaceuticals. In this review, we introduce the transdermal delivery of insulin, a representative peptide drug, and present a transdermal vaccine for malaria as an alternative to injection. Finally, we discuss cutting–edge research on transdermal formulations for the latest nucleic acid drugs.

Journal

  • MEMBRANE

    MEMBRANE 49 (6), 293-299, 2024

    THE MEMBRANE SOCIETY OF JAPAN

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