注射に代わるバイオ医薬品の非侵襲的経皮薬物送達技術

後藤 雅宏, 田中 敬佑, 豊福 淳大

doi:10.5360/membrane.49.293

書誌事項

タイトル別名

Noninvasive Transdermal Drug Delivery Technology for Biopharmaceuticals as an Alternative to Injection
–Breakthroughs by Membranous Approaches–
–膜学的アプローチによるブレークスルー–

説明

The share of biopharmaceuticals is expected to further increase in the future. Biopharmaceuticals, which consist of peptides and proteins, are anticipated to exhibit greater specificity to target molecules within the body compared to small molecule drugs. However, most biopharmaceuticals are administered by injection because they are broken down by enzymes when taken orally. We have been exploring the development of transdermal formulations (e.g., patches or ointments) as an alternative to injectable biopharmaceuticals. In this review, we introduce the transdermal delivery of insulin, a representative peptide drug, and present a transdermal vaccine for malaria as an alternative to injection. Finally, we discuss cutting–edge research on transdermal formulations for the latest nucleic acid drugs.

収録刊行物

膜

膜 49 (6), 293-299, 2024

日本膜学会

詳細情報詳細情報について

CRID: 1390583934062103040

DOI: 10.5360/membrane.49.293

ISSN: 18846440; 03851036

Web Site: https://www.jstage.jst.go.jp/article/membrane/49/6/49_293/_pdf

本文言語コード: ja

データソース種別

JaLC
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抄録ライセンスフラグ: 使用不可

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