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Genetic, Phylogenetic, and Serological Analysis of a Getah Virus Strain Isolated from <i>Culex tritaeniorhynchus</i> Mosquitoes in Nagasaki, Japan in 2022
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- Matsumura Ryo
- Department of Medical Entomology, National Institute of Infectious Diseases, Japan Graduate School of Agriculture, Meiji University, Japan
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- Bannai Hiroshi
- Equine Research Institute, Japan Racing Association, Japan
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- Nemoto Manabu
- Equine Research Institute, Japan Racing Association, Japan
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- Higa Yukiko
- Department of Medical Entomology, National Institute of Infectious Diseases, Japan
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- Kai Izumi
- Department of Medical Entomology, National Institute of Infectious Diseases, Japan Graduate School of Agriculture, Meiji University, Japan
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- Sasaki Toshinori
- Department of Medical Entomology, National Institute of Infectious Diseases, Japan
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- Futami Kyoko
- Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Japan
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- Yoshikawa Akira
- Nagasaki Prefectural Institute for Environmental Research and Public Health, Japan
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- Fujita Ryosuke
- Faculty of Agriculture, Kyushu University, Japan
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- Hino Masato
- Faculty of Agriculture, Kyushu University, Japan
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- Nagata Kosuke
- Faculty of Agriculture, Kyushu University, Japan Hokkaido Research Organization, Japan
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- Kuwata Ryusei
- Faculty of Veterinary Medicine, Okayama University of Science, Japan
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- Kaku Yoshihiro
- Department of Veterinary Science, National Institute of Infectious Diseases, Japan
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- Kobayashi Daisuke
- Department of Medical Entomology, National Institute of Infectious Diseases, Japan Management Department of Biosafety, Laboratory Animal, and Pathogen Bank, National Institute of Infectious Diseases, Japan
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- Minakawa Noboru
- Department of Vector Ecology and Environment, Institute of Tropical Medicine, Nagasaki University, Japan
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- Kasai Shinji
- Department of Medical Entomology, National Institute of Infectious Diseases, Japan
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- Itoyama Kyo
- Graduate School of Agriculture, Meiji University, Japan
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- Maeda Ken
- Department of Veterinary Science, National Institute of Infectious Diseases, Japan
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- Isawa Haruhiko
- Department of Medical Entomology, National Institute of Infectious Diseases, Japan
Bibliographic Information
- Other Title
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- Genetic, Phylogenetic, and Serological Analysis of a Getah Virus Strain Isolated from Culex tritaeniorhynchus Mosquitoes in Nagasaki, Japan in 2022
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Description
<p>Getah virus (GETV), belonging to the genus Alphavirus within the family Togaviridae, is a mosquito-borne virus that causes fever, rash, edema in horses, fatalities, and pregnancy disorders in pigs. It has caused occasional outbreaks in horse populations in Japan, China, and India, and the endemic areas are gradually expanding, particularly in Asia and Oceania. In this study, we isolated a new GETV strain from Culex tritaeniorhynchus mosquitoes collected in Nagasaki Prefecture, Japan, in 2022. Phylogenetic analysis demonstrated that this new strain, 22IH8, was more closely related to previous Chinese strains than to the strains prevalent in Japan in the 2010s. Furthermore, some amino acid substitutions in the viral proteins of strain 22IH8 were similar to those in previous Chinese strains. These results indicate that strain 22IH8 may have recently invaded the Japanese archipelago from mainland Asia. The antiserum against the current vaccine strain MI-110 demonstrated high neutralization activity against the strain 22IH8, indicating the efficiency of the current vaccine for horses in Japan.</p>
Journal
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 78 (2), 71-78, 2025-03-31
National Institute of Infectious Diseases
