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STUDY ON THE USE OF MULTI-ITEM ALLERGY TEST "DROP SCREEN" FOR PEDIATRIC ALLERGIC DISEASES
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- Ito Yoshihiro
- Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science Nano Medical Engineering Laboratory, RIKEN Cluster of Pioneering Research
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- Akimoto Jun
- Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science
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- Otake Naoto
- Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital
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- Obuse Sei
- Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science
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- Ogawa Yuto
- Dynacom Co., Ltd.
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- Miura Junichiro
- Dynacom Co., Ltd.
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- Fujimiya Hitoshi
- Dynacom Co., Ltd.
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- Sato Sakura
- Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital
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- Ebisawa Motohiro
- Department of Allergy, Clinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital
Bibliographic Information
- Other Title
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- 小児アレルギー疾患における多項目アレルギー検査ドロップスクリーンの活用に関する検討
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Description
<p>Background: DropScreen ST-1® is a new onsite simultaneous measurement of specific IgE antibodies for multiple allergens using a small amount of blood and has been clinically utilized since 2020. We compared it with ImmunoCap® which is conventionally performed for each single allergen and investigated the usefulness for pediatric allergy.</p><p>Method: Using serum from 244 people who visited an allergy outpatient clinic, specific IgE antibodies were measured using DropScreen ST-1® and the concordance rate with ImmunoCap® was evaluated, targeting 244 people (under 3 years old). We performed cluster analysis using the Co-Clustering method.</p><p>Results: The positive concordance rate, negative concordance rate, and judgment concordance rate between DropScreen ST-1® and ImmunoCap® were 93.5%, 93.0%, and 89.3%, respectively. In the cluster analysis, with a high Fisher exact probability, it was possible to classify it into 9 clusters on the allergen axis and 5 clusters on the patient axis. Allergens such as egg white, ovomucoid, milk, and mites were found to form characteristic clusters. On the patient axis, the group was classified from those who were highly sensitized to various allergens to those who were highly sensitized to specific allergens.</p><p>Conclusion: DropScreen ST-1® and ImmunoCap® showed a high correlation. Cluster analysis of sensitization patterns has become possible through a specific IgE test that measures multiple items simultaneously.</p>
Journal
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- Japanese Journal of Allergology
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Japanese Journal of Allergology 74 (2), 63-72, 2025-04-10
Japanese Society of Allergology
