Ocular Adverse Effects of Hydroxychloroquine

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  • Shinoda Kei
    Department of Ophthalmology, Saitama Medical University Hospital

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Other Title
  • ヒドロキシクロロキンによる眼部副作用

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Description

Chloroquine retinopathy is a type of retinopathy in which the macula is impaired bilaterally from long-term administration of chloroquine（CQ）. It is one of the three major drug toxicities in Japan. Consequently, CQ use has been limited for over 50 years. In 2015, hydroxychloroquine（HCQ）was approved for systemic and cutaneous lupus erythematosus. Similar retinopathy may occur with oral administration of HCQ, although the frequency is relatively low compared to CQ retinopathy. The treatment is drug cessation, but progression or worsening may occur even after the cessation; therefore, early detection is important. Factors such as the cumulative dose, liver and renal dysfunction, and aging influence its onset, and collaboration between the doctor prescribing HCQ and the ophthalmologist is important.

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