ARTIFICIAL RED CELLS (HEMOGLOBIN VESICLES) AS A TRANSFUSION ALTERNATIVE AND THEIR NEW CLINICAL APPLICATIONS

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  • 人工赤血球（ヘモグロビン ベシクル）製剤の新しい利用法

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<p>The blood donation and transfusion system has contributed significantly to the human health and welfare. However, there still exit emergency situations where blood transfusion is not available. To complement the blood transfusion system, we have developed artificial red cells (hemoglobin vesicles, Hb-V) with the intention of their clinical use. Hemoglobin is purified from expired NAT-inspected RBCs via virus inactivation and removal procedures and regenerated as storable artificial red cells. We established a basis for production processes and clarified the safety and efficacy of Hb-V as a transfusion alternative through preclinical studies with the help of grants from MHLW and AMED. On the other hand, new potential applications of Hb-V are being clarified by taking the advantages of its unique physicochemical properties.</p>

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