Experimental studies on oral radiation death

DOI IR
  • Sugie Tsuneto
    Department of Dental Radiology, School of Dentistry, Iwate Medical University

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  • 放射線口腔死に関する実験的研究

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<p>There have been few reports of oral radiation death and the ethiology of this form of death has not been fully investigated to date.</p><p>The purpose of this paper is to clarify the genesis of oral radiation death.</p><p>The animals used in this experiment were ddN female mice weighing 23 to 26g. The mice were given X-irradiation to various areas of the head.</p><p>The results were as follows:</p><p>1. The mean survival time after 2400R irradiation was 12 days in the wholehead group, 14.8 days in the maxillary group and 16.8 days in the mandibulary group, respectively.</p><p>2. The spleen to body weight ratio (s/bw) of the control mice was 0.0098土0.0014 and the ratio s/bw of the starved irradiated mice decreased drastically to 0.0013土0.0007.</p><p>On the other hand, the value of the ratio on the irradiated mice decreased in proportion to the dosage and remained at nearly 0.0035.</p><p>3. There were no favorable effects on the survival rate of irradiated mice even when fed by forced nutrition. The excretion rate of 131I-HSA in the feces of irradiated mice increased relnarkably at an early stage of the irradiation to whole-head as compared to the control mice.</p><p>From these findings, it was thought the causes of oral radiation death may result from general irradiation damage to certain areas including the spleen and the intestines in addition to the starvatlon.</p>

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