Phosphine Oxide-Catalyzed Asymmetric Aldol Reactions and Double Aldol Reactions

DOI Web Site Web Site PubMed 被引用文献1件 参考文献73件 オープンアクセス
  • Kotani Shunsuke
    Priority Organization for Innovation and Excellence Kumamoto University Graduate School of Pharmaceutical Sciences, Kumamoto University

書誌事項

公開日
2019-06-01
資源種別
journal article
DOI
  • 10.1248/cpb.c19-00015
公開者
公益社団法人 日本薬学会

この論文をさがす

説明

<p>Chiral phosphine oxides successfully catalyze asymmetric cross-aldol reactions of various carbonyl compounds in a highly enantioselective manner. The phosphine oxide catalysts coordinate to chlorosilanes to form chiral hypervalent silicon complexes in situ, which activate both aldol donors and acceptors, thus realizing cross-aldol reactions between a ketone and an aldehyde, between two aldehydes, between two ketones, and of 2,6-diketones. The use of phosphine oxide catalysis can be further extended to achieve the first catalytic enantioselective double aldol reactions, realizing one-pot stereoselective construction of up to four stereogenic centers.</p>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (73)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ