The significance of human papillomavirus screening in urine samples among men

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  • Shigehara Kazuyoshi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Nakagawa Tomomi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Sakamoto Jiro
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Nakashima Kazufumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Yaegashi Hiroshi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Kawaguchi Shohei
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
  • Nakashima Takao
    Department of Urology, Ishikawa Prefectural Central Hospital
  • Shimamura Masayoshi
    Department of Urology, Nomi City Hospital
  • Kitamura Tadaichi
    Japanese Foundation for Sexual Health Medicine
  • Mizokami Atsushi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science

Bibliographic Information

Other Title
  • 男性における尿検体を用いたHuman Papillomavirus検査の意義
  • ダンセイ ニ オケル ニョウケンタイ オ モチイタ Human Papillomavirus ケンサ ノ イギ

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Abstract

Objective: We assessed the significance of human papillomavirus (HPV) screening in urine samples among men.Patients and Methods: We enrolled 788 patients who attended urological outpatient clinics and collected glans-rubbed samples and urine samples from each one. Following DNA extraction, HPV-DNA testing and genotyping were performed using a polymerase chain reaction-based Luminex method.Results: The mean age of the cohort was 53.9±20.8 years. The HPV prevalence rate was 24.1% (95%CI: 21.1–27.1%) and 6.6% (95%CI: 4.8–8.4%) in the glans and urine samples, respectively. Among the HPV-positive samples, high-risk HPV was detected in 54.7% and 50.0% of the glans and urine samples, respectively. The sensitivity and specificity of HPV detection in urine samples for genital HPV infection were 65% (95%CI: 52–78%) and 79% (95%CI: 76–82%), respectively. HPV16 was detected in 11 cases (5.8%) in glans samples and 12 (23%) in urine samples, and the prevalence was significantly higher in urine than in glans samples.Conclusions: Although glans-rubbed samples can be used for genital HPV screening among men, HPV16 was significantly prevalent in urine compared with glans samples, suggesting that urine samples were more suited to the investigation of HPV-induced pathogenesis in the urinary tract.

Journal

  • 日本性感染症学会誌

    日本性感染症学会誌 30 (1), 15-20, 2019-08-31

    Japanese Society for Sexually Transmitted Infections

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