Clinicopathological characteristics and pathogenic germline variants of gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS)

DOI
  • Mitsui Yasuhiro
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences
  • Teramae Satoshi
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences
  • Tanaka Kumiko
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences
  • Fujimoto Shota
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences
  • Kitamura Shinji
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences
  • Okamoto Koichi
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences
  • Miyamoto Hiroshi
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences
  • Sato Yasushi
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences
  • Muguruma Naoki
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences
  • Takayama Tetsuji
    Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences

Bibliographic Information

Other Title
  • Gastric adenocarcinoma and proximal polyposis of the stomach（GAPPS）における<i>APC</i>遺伝子生殖細胞系列バリアントおよび臨床病理学的特徴

Description

Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is an autosomal dominant inherited disease clinically characterized by gastric cancer and fundic gland polyposis (FGPsis). Germline variants of the APC promotor 1B have been reported as pathogenic variants in GAPPS families. Most GAPPS families have been reported in Western countries; however, only a few GAPPS families have been reported from Japan. Appropriate surveillance including gastrointestinal endoscopy and indication of surgical gastrectomy for GAPPS patients have not been established because of the lack of knowledge of GAPPS and the high positivity rate for Helicobacter pylori infection in Japan. A large-scale investigation of clinicopathological characteristics and pathology is required to establish of a surveillance and treatment strategy for GAPPS.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390846609808769024
  • NII Article ID
    130007803740
  • DOI
    10.18976/jsft.19.2_53
  • ISSN
    21896674
    13461052
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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