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- Jeong Heonuk
- 東京大学
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- Yang Xiaoguang
- 東京大学
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- 牛田 多加志
- 東京大学
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- 古川 克子
- 東京大学
書誌事項
- タイトル別名
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- Control of Osteogenic Differentiation Timing by Substrate Microtopography
抄録
<p>Recent researches have shown that enhanced focal adhesion between cells and extracellular matrix (ECM) and intracellular actin polymerization can accelerate cellular functions like adhesion and differentiation. In this study, mesenchymal stem cells (MSCs) from Sprague Dawley (SD) rats were cultured on the substrates with surface topography, the groove patterns in micro scale, to verify the relationship between cell adhesion and differentiation. Impeded osteogenic differentiation was observed on cells cultured with micro-topographic substrates. This result may be caused by the decrease in focal adhesion. Through this study, it is expected that the technique to control bone regeneration by surface microtopography will be one more step closer.</p>
収録刊行物
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- 年次大会
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年次大会 2019 (0), J05401-, 2019
一般社団法人 日本機械学会
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詳細情報 詳細情報について
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- CRID
- 1390846609816547840
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- NII論文ID
- 130007816260
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- ISSN
- 24242667
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可