Conditioned Media from Human Dental Pulp Stem Cells Prevent Radiation-induced Skin Injury

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  • KAWARABAYASHI Keita
    Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School Pediatric Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School
  • KANO Fumiya
    Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School
  • HASHIMOTO Noboru
    Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School
  • HIBI Hideharu
    Department of Oral and Maxillofacial Surgery Nagoya University Graduate School of Medicine
  • IWAMOTO Tsutomu
    Pediatric Dentistry, Institute of Biomedical Sciences, Tokushima University Graduate School
  • YAMAMOTO Akihito
    Department of Tissue Regeneration, Institute of Biomedical Sciences, Tokushima University Graduate School

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Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. In this study, we investigated the impact of SHED-conditioned medium (SHED-CM) on radiation-induced skin injury. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema. Intra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration.

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