Developmental immunotoxicity test of dinotefuran administered to mice in drinking water
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- SAIGA Aya
- Tokyo Metropolitan Institute of Public Health
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- TADA Yukie
- Tokyo Metropolitan Institute of Public Health
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- NAKAMURA Mari
- Tokyo Metropolitan Institute of Public Health
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- HOJO Motoki
- Tokyo Metropolitan Institute of Public Health
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- IKUSHIMA Kiyomi
- Tokyo Metropolitan Institute of Public Health
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- MAENO Ai
- Tokyo Metropolitan Institute of Public Health
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- YUZAWA Katsuhiro
- Tokyo Metropolitan Institute of Public Health
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- KUBO Yoshikazu
- Tokyo Metropolitan Institute of Public Health
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- ANDO Hiroshi
- Tokyo Metropolitan Institute of Public Health
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- NAGASAWA Akemichi
- Tokyo Metropolitan Institute of Public Health
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- TANAKA Kazuyoshi
- Tokyo Metropolitan Institute of Public Health
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- SUZUKI Toshinari
- Tokyo Metropolitan Institute of Public Health
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- INOMATA Akiko
- Tokyo Metropolitan Institute of Public Health
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- MORIYASU Takako
- Tokyo Metropolitan Institute of Public Health
Bibliographic Information
- Other Title
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- ジノテフランの飲水投与による発達免疫毒性試験
Abstract
<p>Dinotefuran has been shown to be transferred to offspring via the placenta or milk, which raises concerns about transgenerational effects. Here, ICR mice were given 0, 0.02 and 0.2% of dinotefuran diluted in water from GD 0 to PND 50, and the dams and their offspring were evaluated, focusing on the immunotoxicity. Some dosed groups showed a slight decrease of the WBC in maternal blood, and a tendency of increase of the proportion of Gr-1+ cells in the bone marrows of the mothers and the offspring. No statistically significant changes were observed in all of the parameters. </p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-106-, 2020
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390848647544885760
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- NII Article ID
- 130007898228
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed