Developmental immunotoxicity test of dinotefuran administered to mice in drinking water

DOI

Bibliographic Information

Other Title
  • ジノテフランの飲水投与による発達免疫毒性試験

Abstract

<p>Dinotefuran has been shown to be transferred to offspring via the placenta or milk, which raises concerns about transgenerational effects. Here, ICR mice were given 0, 0.02 and 0.2% of dinotefuran diluted in water from GD 0 to PND 50, and the dams and their offspring were evaluated, focusing on the immunotoxicity. Some dosed groups showed a slight decrease of the WBC in maternal blood, and a tendency of increase of the proportion of Gr-1+ cells in the bone marrows of the mothers and the offspring. No statistically significant changes were observed in all of the parameters. </p>

Journal

Details 詳細情報について

  • CRID
    1390848647544885760
  • NII Article ID
    130007898228
  • DOI
    10.14869/toxpt.47.1.0_p-106
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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