Optimization of assessment method for drug induced contractile response in human induced pluripotent stem cell-derived cardiac cell sheet-tissue
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- KATO Eriko
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- HINATA Yuto
- Ogino Memorial Laboratory, Nihon Kohden Corporation
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- KAGAWA Yuki
- Ogino Memorial Laboratory, Nihon Kohden Corporation
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- KUBO Hirotsugu
- Ogino Memorial Laboratory, Nihon Kohden Corporation
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- TANIGUCHI Tomohiko
- Advanced Biosignal Safety Assessment, Eisai Co., Ltd.
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- YOSHINAGA Takashi
- Advanced Biosignal Safety Assessment, Eisai Co., Ltd.
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- BABA Atsushi
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- IKEGAYA Yuji
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- SAWADA Kohei
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
Bibliographic Information
- Other Title
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- ヒトiPS細胞由来心筋細胞シートを用いた薬剤の収縮評価方法の最適化
Description
<p>Isometric contractile force was recorded using cell-sheet-tissues. The drug effects were evaluated at 3 different electrical stimulation conditions as follows; spontaneous beat, 1 Hz pacing, and spontaneous beat after preconditioning (72hr stimulation at 2 Hz for maturation purpose). Drugs which were difficult to measure under spontaneous beat could be evaluated under 1 Hz pacing without beating arrest, or exhibited large increase of contractile force after preconditioning. Taken together, this method can be a very useful tool for preclinical study.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-83E-, 2020
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390848647545192832
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- NII Article ID
- 130007898531
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed
