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- 名取 良浩
- 東北医科薬科大学薬学部分子薬化学教室
書誌事項
- タイトル別名
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- Synthesis of L-Iminofuranoses and Their Biological Evaluations
- L-イミノフラノース ユウドウタイ ノ ゴウセイ ト ソノ セイブツ カッセイ ヒョウカ ニ カンスル ケンキュウ
この論文をさがす
説明
<p>Iminosugars are one of the compounds that mimic the structure of monosaccharides. Such sugar mimics have the ability to effectively and specifically inhibit various glycosidases and glycosyltransferases. After studying iminopyranose, miglitol, which has α-glucosidase inhibitory activity, was approved and used in the clinical treatment of diabetes. This study focused on l-iminofuranose derivatives to develop new anti-diabetic drug. As a result, it was found that l-iminofuranose having an alkyl group at C1 position show potent α-glucosidase inhibitory activity. Further structural-activity relationship studies were conducted, and interesting findings were obtained. This paper describes the details of those research developments.</p>
収録刊行物
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- 薬学雑誌
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薬学雑誌 141 (1), 15-24, 2021-01-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390849931318313600
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- NII論文ID
- 130007964844
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 031230171
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- PubMed
- 33390442
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可