Lipid droplets are formed in 2-cell-like cells

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  • FURUTA Asuka
    Laboratory for Epigenetic Regulation, Department of Bio-Science, Nagahama Institute of Bio-Science and Technology, Shiga 526-0829, Japan
  • NAKAMURA Toshinobu
    Laboratory for Epigenetic Regulation, Department of Bio-Science, Nagahama Institute of Bio-Science and Technology, Shiga 526-0829, Japan

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<p> Embryonic stem (ES) cells, derived from the inner cell mass of a blastocyst, are believed to pluripotent cells and give rise to embryonic, but not extraembryonic, tissues. In mice, totipotent 2-cell stage embryo-like (2-cell-like) cells, which are identified by reactivation of murine endogenous retrovirus with leucin transfer RNA primer (MuERV-L), arise at a very few frequencies in ES cell cultures. Here, we found that a lipid droplet forms during the transition from ES cells to 2-cell-like cells, and we propose that 2-cell-like cells utilize a unique energy storage and production pathway.</p>

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