Usefulness of in vitro embryogenesis to assess teratogenic effect of nucleic acid analogues
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- OKA Hiroyuki
- Laboratory for Drug Discovery and Development, SHIONOGI & CO., LTD.
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- WATANABE Minami
- Laboratory for Drug Discovery and Development, SHIONOGI & CO., LTD.
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- OIDA Tomomi
- Shionogi Techno Advance Research & Co., Ltd.
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- YOSHIMURA Masatoshi
- Shionogi Techno Advance Research & Co., Ltd.
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- OKAGAWA Yuki
- Shionogi Techno Advance Research & Co., Ltd.
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- YOSHIDA Mei
- Shionogi Techno Advance Research & Co., Ltd.
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- NISHIMURA Kyouhei
- Laboratory for Drug Discovery and Development, SHIONOGI & CO., LTD.
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- MIYAGAWA Masayoshi
- Laboratory for Medicinal Chemistry Research, SHIONOGI & CO., LTD.
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- TAKAGI Shingo
- Laboratory for Drug Discovery and Development, SHIONOGI & CO., LTD.
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- ANDO Yoshinori
- Laboratory for Drug Discovery and Disease Research, SHIONOGI & CO., LTD.
Bibliographic Information
- Other Title
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- 核酸アナログ医薬品におけるin vitro催奇形性評価系の有用性
Abstract
<p>Nucleic acid analogs are highly effective therapeutic agents for viral infections. Teratogenicity is often observed in this class, and its avoidance is important. We evaluated usefulness of Whole Embryo Culture for screening teratogenicity of nucleic acid analogues. We applied analogs which were teratogenic in rats to the WEC and confirmed abnormal embryogenesis except for purine base analogs. In conclusion, the WEC is useful for assess teratogenicity of nucleic acid analogs other than purine base analogs. Further studies are required to avoid false negatives of purine base analogs.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), O-38-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390851961197783936
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- NII Article ID
- 130008073630
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed