Elucidation of the mechanisms of renal toxicity caused by polypeptide antibiotics

DOI
  • KAGI Tomohiro
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • NAGANUM Rio
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • INOUE Aya
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • HIRATA Yusuke
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • NOGUCHI Takuya
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.
  • MATSUZAWA Atsushi
    Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.

Bibliographic Information

Other Title
  • ポリペプチド系抗菌薬による腎毒性発現機構の解明

Abstract

<p>Colistin, a class of polypeptide antibiotics that is effective against multidrug-resistant Gram-negative bacillus, is conceived as an essential drug for infectious diseases. Meanwhile, colistin frequently causes renal dysfunction that limits its clinical use. However, toxic mechanisms of colistin remain unknown. In this study, we investigated cellular responses to colistin in macrophages that play a major role in inflammation, and found that colistin stimulates IL-1β and HMGB1 release via two distinct mechanisms. These observations may provide insights into colistin-induced renal dysfunction.</p>

Journal

Details 詳細情報について

  • CRID
    1390851961199607424
  • NII Article ID
    130008073631
  • DOI
    10.14869/toxpt.48.1.0_p-120s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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