P20 超音波依存的な細胞質内への物質輸送法

DOI

書誌事項

タイトル別名
  • P20 Ultrasound-dependent cytosolic delivery of bioactive molecules

抄録

Recently, methods for delivery of peptide and RNA to target cells are widely studied for cell research and drug delivery strategies. However, the delivery methods sometimes have problems such as cytotoxicity and ineffective delivery. In some methods, target molecules tend to be trapped in endosome and degraded by lysosome when introduced to cells. In this study, ultrasound-dependent peptide / nanoparticle delivery method was developed. We developed a molecular conjugate of a cell-penetrating peptide, a sonosensitizer and a functional peptide / nanoparticle. This molecule was trapped in endosome when cells were incubated with the molecule. However, we succeeded in cytoplasmic delivery of the molecule that escape from endosome by ultrasound irradiation.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1390854968910577792
  • DOI
    10.20577/pamjss.26.0_59
  • ISSN
    24241512
  • 本文言語コード
    ja
  • データソース種別
    • JaLC
  • 抄録ライセンスフラグ
    使用不可

問題の指摘

ページトップへ