P20 Ultrasound-dependent cytosolic delivery of bioactive molecules

DOI
  • Nagahiro Shota
    Graduate school of natural science and technology, Okayama University
  • Inaba Yuki
    Graduate school of natural science and technology, Okayama University
  • Matuura Eiji
    Collaborative Research Center for OMIC, Okayama University
  • Watanabe Kazunori
    Graduate school of natural science and technology, Okayama University
  • Ohtsuki Takashi
    Graduate school of natural science and technology, Okayama University

Bibliographic Information

Other Title
  • P20 超音波依存的な細胞質内への物質輸送法

Abstract

Recently, methods for delivery of peptide and RNA to target cells are widely studied for cell research and drug delivery strategies. However, the delivery methods sometimes have problems such as cytotoxicity and ineffective delivery. In some methods, target molecules tend to be trapped in endosome and degraded by lysosome when introduced to cells. In this study, ultrasound-dependent peptide / nanoparticle delivery method was developed. We developed a molecular conjugate of a cell-penetrating peptide, a sonosensitizer and a functional peptide / nanoparticle. This molecule was trapped in endosome when cells were incubated with the molecule. However, we succeeded in cytoplasmic delivery of the molecule that escape from endosome by ultrasound irradiation.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390854968910577792
  • DOI
    10.20577/pamjss.26.0_59
  • ISSN
    24241512
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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