P20 超音波依存的な細胞質内への物質輸送法
書誌事項
- タイトル別名
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- P20 Ultrasound-dependent cytosolic delivery of bioactive molecules
抄録
Recently, methods for delivery of peptide and RNA to target cells are widely studied for cell research and drug delivery strategies. However, the delivery methods sometimes have problems such as cytotoxicity and ineffective delivery. In some methods, target molecules tend to be trapped in endosome and degraded by lysosome when introduced to cells. In this study, ultrasound-dependent peptide / nanoparticle delivery method was developed. We developed a molecular conjugate of a cell-penetrating peptide, a sonosensitizer and a functional peptide / nanoparticle. This molecule was trapped in endosome when cells were incubated with the molecule. However, we succeeded in cytoplasmic delivery of the molecule that escape from endosome by ultrasound irradiation.
収録刊行物
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- ソノケミストリー討論会講演論文集
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ソノケミストリー討論会講演論文集 26 (0), 59-60, 2017
日本ソノケミストリー学会
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詳細情報 詳細情報について
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- CRID
- 1390854968910577792
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- ISSN
- 24241512
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可