Improvement in Nasal Allergy-like Symptoms after 4 Weeks Supplementation of Soluble Dietary Fiber, Fuji FF Inulin : A Randomized, Placebo-controlled, Double-blind, Parallel-group, Clinical Study

DOI IR (HANDLE) Open Access
  • KIKUSHIMA Kenji
    Department of Integrative Anatomy, Nagoya City University Graduate School of Medical Sciences
  • NAGAE Masumi
    Laboratory of Systematic Forest and Forest Products Sciences, Division of Sustainable Bioresources Science, Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University
  • HARA Kenjiro
    Research and Development, Fuji-Nihon Seito Co., Ltd.
  • OHNUKI Keiko
    User Life Science Co., Ltd.
  • SHIMIZU Kuniyoshi
    Laboratory of Systematic Forest and Forest Products Sciences, Division of Sustainable Bioresources Science, Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University
  • OHNUKI Koichiro
    Laboratory of Systematic Forest and Forest Products Sciences, Division of Sustainable Bioresources Science, Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University Department of Biological and Environmental Chemistry, Kindai University

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Other Title
  • 水溶性食物繊維Fuji FFイヌリン4週間摂取によるアレルギー性鼻炎様症状改善効果 : ランダム化プラセボ対照二重盲検並行群間比較試験

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Allergies are caused by abnormalities in the immune tolerance mechanism mediated by regulatory T cells (Treg), and the metabolites of the dietary fibers are important for the oral immune tolerance mechanism. Inulin acts as a dietary fiber and changes the intestinal microflora, which is expected to regulate the immune tolerance mechanism and to be a new treatment for allergies. In this study, we conducted a randomized, placebo-controlled, double-blind, parallel-group study in 49 adult subjects (13 males and 36 females) with various allergic symptoms to examine the effects of the supplementation of Fuji FF, a enzymatic synthesized soluble inulin, on allergic symptoms and mucosal immunity. Subjects took Fuji FF or placebo for 4 weeks, and changes in immune function were verified by two questionnaires and saliva tests. Though no clear improvements were found from Dermatology Life Quality Index (DLQI) and the saliva tests, the result of Japan Allergic Rhinitis Standard Quality of Life Questionnaire (JRQLQ) suggested the effectiveness in the suppression of allergic rhinitis symptoms. Our study indicates that Fuji FF can be applied as a treatment for nasal allergy-like symptoms.

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