Histopathological findings of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
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- KAGE Masayoshi
- Department of Medical Engineering, Junshin Gakuen University
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- AISHIMA Shinichi
- Department of Pathology and Microbiology, Faculty of Medicine, Saga University
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- KUSANO Hironori
- Department of Pathology, School of Medicine, Kurume University
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- YANO Hirohisa
- Department of Pathology, School of Medicine, Kurume University
Bibliographic Information
- Other Title
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- 非アルコール脂肪肝疾患と非アルコール性脂肪肝炎の病理組織所見
Description
<p>Nonalcoholic fatty liver disease (NAFLD) is based on the concept of pathological morphology as well as clinical findings, and is broadly categorized into nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). The differential diagnosis between NAFL and NASH is important because NASH has the potential to progress to cirrhosis and hepatocellular carcinoma. NAFL is simple hepatic steatosis without hepatocellular injury, while NASH is characterized by macrovesicular steatosis, inflammation, and ballooning hepatocytes with a predominantly centrilobular (zone 3) distribution. Liver biopsy is a useful test for diagnosing NAFLD, but it is invasive. Therefore, various noninvasive methods including diagnostic imaging have been developed in recent years. To verify their usefulness, it is necessary to clarify in detail how the pathological findings are reflected in the image findings as imaging and histopathological findings are closely related. We describe the main histological features of NAFLD, i.e., steatosis, inflammation, ballooning hepatocytes, Mallory-Denk bodies, and fibrosis, as well as the evolutional process to liver cirrhosis.</p>
Journal
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- Choonpa Igaku
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Choonpa Igaku 49 (5), 427-432, 2022
The Japan Society of Ultrasonics in Medicine