Right Ventricular Strain Derived from <sup>13</sup>N-ammonia PET and Myocardial Ischemia

DOI IR (HANDLE) Open Access
  • Kawakubo Masateru
    Department of Health Sciences, Faculty of Medical Sciences, Kyushu University
  • Nagao Michinobu
    Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University
  • Yamamoto Atsushi
    Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University
  • Nakao Risako
    Department of Cardiology, Tokyo Women's Medical University
  • Matsuo Yuka
    Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University
  • Kaneko Koichiro
    Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University
  • Watanabe Eri
    Department of Cardiology, Tokyo Women's Medical University
  • Sakai Akiko
    Department of Cardiology, Tokyo Women's Medical University
  • Sasaki Masayuki
    Department of Health Sciences, Faculty of Medical Sciences, Kyushu University
  • Sakai Shuji
    Department of Diagnostic Imaging & Nuclear Medicine, Tokyo Women's Medical University

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Other Title
  • 高解像<sup>13</sup>N-アンモニアPET画像の feature-trackingによる右心室ストレインと心筋虚血との関連

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Description

Objective: It is important to assess myocardial motion for not only left ventricle but also right ventricle. We developed a feature-tracking (FT) algorithm for use with electrocardiography-gated high-resolution 13N-ammonia positron emission tomography (PET) imaging. Previously, we reported that the left ventricular strain value derived from PET-FT analysis can detect a decrease of ischemic myocardium motion. Further, the PET-derived left ventricular longitudinal strain (LS) value was validated referred to cardiac magnetic resonance. In the present research, we applied right ventricular (RV) strain analysis based on the FT algorithm to high-resolution 13N-ammonia PET images, and investigated the association between myocardial ischemia and RV myocardial motion.<br>Methods: Ninety-three patients with coronary artery stenosis >50%, diagnosed by coronary computed tomography angiography, and 10 controls were retrospectively analyzed. RV-LS in the free wall was measured by a FT technique on the resting and stressed 13N-ammonia PET images of horizontal long-axis slices. The patients were sub-grouped according to summed stress score (SSS) values: SSS>12 as severe ischemia [n=13], 4≤SSS≤12 as moderate ischemia [n=29], and SSS<4 as normal [n=51]. Stress and resting RV-LS were compared in each of the four groups. Multiple comparisons of RV-LS among the four groups were performed in the stress and resting state.<br>Results: Decreased absolute RV-LS values at stress in the groups of severe and moderate ischemia were observed with respect to those in the groups of normal and control. Increased absolute RV-LS values at stress state in patients with normal and control were observed with respect to those at resting state.<br>Conclusion: We measured RV myocardial LS using FT in high-resolution cine imaging of 13N-ammonia PET. The results of this study suggest that PET-derived RV-LS is useful for detecting reduced RV myocardial motion due to ischemia in the patients with coronary artery disease.

Journal

  • SHINZO KAKU IGAKU

    SHINZO KAKU IGAKU 25 (1), 13-17, 2023

    Japanese Society of Nuclear Cardiology

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