Apolipoprotein E-associated Lipoprotein Glomerulo-tubulopathy

  • Tanimizu Hikaru
    Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
  • Hara Risa
    Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
  • Sekine Akinari
    Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
  • Inoue Noriko
    Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
  • Hasegawa Eiko
    Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
  • Tanaka Kiho
    Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
  • Kono Kei
    Department of Pathology, Toranomon Hospital Toranomon, Japan
  • Kinowaki Keiichi
    Department of Pathology, Toranomon Hospital Toranomon, Japan
  • Ohashi Kenichi
    Department of Pathology, Toranomon Hospital Toranomon, Japan Department of Human Pathology, Tokyo Medical Dental University, Japan
  • Okubo Minoru
    Section of Lipid Research and Department of Endocrinology and Metabolism, Toranomon Hospital, Japan
  • Yamaguchi Yutaka
    Yamaguchi's Pathology Laboratory, Japan
  • Kang Dedong
    Department of Anatomy, Showa University School of Medicine, Japan
  • Honda Kazuho
    Department of Anatomy, Showa University School of Medicine, Japan
  • Saito Takao
    Sanko Clinic, Japan
  • Sawa Naoki
    Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
  • Ubara Yoshifumi
    Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan
  • Hoshino Junichi
    Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Toranomon, Japan

抄録

<p>A 32-year-old man was admitted for the evaluation of proteinuria (5.69 g/day). A light microscopic examination showed markedly dilated glomerular capillary loops with vacuolated areas in many glomeruli, and vacuolated areas were seen on peritubular capillaries in the tubulointerstitium. When electron microscopy specimens prepared by pre-fixation with glutaraldehyde and post-fixation with osmium tetroxide were used for oil red staining, the deposition was confirmed on the affected areas. A genetic analysis of apoE showed that the lipoprotein glomerulopathy was due to apoE-Sendai (Arg145Pro, p.R163P) heterozygosity, which was found in not only the patient but also his mother and twin brother. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 62 (15), 2209-2214, 2023-08-01

    一般社団法人 日本内科学会

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