Invasive pneumococcal disease due to non-vaccine serotype 10A Streptococcus pneumoniae in an infant

DOI
  • Honda Kana
    Department of Pediatrics, Showa University School of Medicine
  • Kanazawa Takeru
    Childrenʼs Medical Center, Showa University Koto Toyosu Hospital
  • Ohne Marina
    Childrenʼs Medical Center, Showa University Northern Yokohama Hospital
  • Suitou Tatsuya
    Department of Pediatrics, Showa University School of Medicine
  • Yoshida Yurika
    Childrenʼs Medical Center, Showa University Koto Toyosu Hospital
  • Kamijo Kaori
    Childrenʼs Medical Center, Showa University Koto Toyosu Hospital
  • Matsuhashi Kazuhiko
    Childrenʼs Medical Center, Showa University Koto Toyosu Hospital
  • Abe Yoshifusa
    Childrenʼs Medical Center, Showa University Koto Toyosu Hospital

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Other Title
  • 肺炎球菌結合型ワクチン非含有血清型 10A による 侵襲性肺炎球菌感染症の 1 乳児例

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Abstract

We report the case of a 2-month-old boy who was hospitalized due to fever after a single administration of the 13-valent pneumococcal conjugate vaccine (PCV13) and subsequently diagnosed with invasive pneumococcal disease (IPD). Blood culture identified Streptococcus pneumoniae serotype 10A, a non-PCV13 serotype. Despite a significant decline in the number of children with IPD after the introduction of PCV13, the rate of IPD due to non-PCV13 serotypes has increased. Pneumococcal vaccination cannot completely prevent IPD, and IPD due to non-vaccine serotypes should be considered in children with fever.

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