Development of the Functional Intestinal Metabolite Urolithin A

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  • 機能性腸内代謝物素材ウロリチンAの開発
  • (JSNFS Award for Technology and Innovation (2023))
  • (令和5年度日本栄養・食糧学会技術賞受賞)

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<p>Urolithins are functional polyphenols produced by human intestinal bacteria metabolizing ellagitannin and ellagic acid, contained in pomegranates and their hydrolysates. We have succeeded in producing urolithin A in one pot from ellagic acid as a starting material by co-culturing urolithin A-producing bacteria and urolithin C-producing bacteria. Based on this technology, in May 2021 we developed a process that can stably ferment and produce urolithin A through co-culture, thus making it possible to establish an industrial-level manufacturing process and commercialize a food material containing 10% urolithin A (Urorich®). Urolithin A has been reported to have antioxidant and anti-inflammatory effects in addition to mitophagy-promoting effects. We have clarified that urolithin A has functionalities such as suppression of lipid droplet accumulation, suppression of osteoclast differentiation, alteration of human epidermal keratinocytes, and anti-allergic effects on hay fever. Furthermore, we evaluated its vascular endothelial function in humans and clarified the mechanism responsible. Urolithin may contribute to the maintenance and improvement of health as a functional material that meets current needs for human well-being.</p>

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