薬用植物から得られる化学的に不安定な成分を使用した機能性化合物の開発研究

DOI Web Site 参考文献28件

書誌事項

タイトル別名
  • Development of Functional Compounds Using Chemically Unstable Compounds Obtained from Medicinal Plants

抄録

<p>Sulfur- or nitrogen-containing compounds from medicinal plants exhibit various biological activities such as anticancer potential. Developing efficient strategies to isolate or synthesize these compounds or their derivatives is a remarkable achievement. We have isolated several sulfur-containing compounds such as tetrahydro-2H-difuro[3,2-b:2′,3′-c]furan-5(5aH)-one derivatives from Allium plants. We have devised a unique approach for the rapid preparation of thiopyranones using the regioselective sequential double Diels–Alder reaction; we used a naturally-occurring chemically-unstable intermediate such as thioacrolein, which is produced from allicin, a major component in garlic. The cytotoxicity of the synthetic thiopyranones against cancer stem cells (CSCs) was equal to or higher than that of (Z)-ajoene, the reference compound.</p>

収録刊行物

  • 薬学雑誌

    薬学雑誌 144 (1), 21-26, 2024-01-01

    公益社団法人 日本薬学会

参考文献 (28)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ