Shared and Reciprocal Mechanisms Between Heart Failure and Cancer　― An Emerging Concept of Heart-Cancer Axis ―

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  • Kadowaki Hiroshi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
  • Akazawa Hiroshi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
  • Shindo Akito
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
  • Ueda Tomomi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
  • Ishida Junichi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
  • Komuro Issei
    Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo International University of Health and Welfare

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<p>Epidemiological evidence of increased risks of cancer in heart failure (HF) patients and HF in cancer patients has suggested close relationships between the pathogenesis of both diseases. Indeed, HF and cancer share common risk factors, including aging and unhealthy lifestyles, and underlying mechanisms, including activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, chronic inflammation, and clonal hematopoiesis of indeterminate potential. Mechanistically, HF accelerates cancer development and progression via secreted factors, so-called cardiokines, and epigenetic remodeling of bone marrow cells into an immunosuppressive phenotype. Reciprocally, cancer promotes HF via cachexia-related wasting and metabolic remodeling in the heart, and possibly via cancer-derived extracellular vesicles influencing myocardial structure and function. The novel concept of the “heart-cancer axis” will help in our understanding of the shared and reciprocal relationships between HF and cancer, and provide innovative diagnostic and therapeutic approaches for both diseases.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 88 (2), 182-188, 2024-01-25

    一般社団法人 日本循環器学会

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