Shared and Reciprocal Mechanisms Between Heart Failure and Cancer ― An Emerging Concept of Heart-Cancer Axis ―
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- Kadowaki Hiroshi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Akazawa Hiroshi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Shindo Akito
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Ueda Tomomi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Ishida Junichi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Komuro Issei
- Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo International University of Health and Welfare
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Abstract
<p>Epidemiological evidence of increased risks of cancer in heart failure (HF) patients and HF in cancer patients has suggested close relationships between the pathogenesis of both diseases. Indeed, HF and cancer share common risk factors, including aging and unhealthy lifestyles, and underlying mechanisms, including activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, chronic inflammation, and clonal hematopoiesis of indeterminate potential. Mechanistically, HF accelerates cancer development and progression via secreted factors, so-called cardiokines, and epigenetic remodeling of bone marrow cells into an immunosuppressive phenotype. Reciprocally, cancer promotes HF via cachexia-related wasting and metabolic remodeling in the heart, and possibly via cancer-derived extracellular vesicles influencing myocardial structure and function. The novel concept of the “heart-cancer axis” will help in our understanding of the shared and reciprocal relationships between HF and cancer, and provide innovative diagnostic and therapeutic approaches for both diseases.</p>
Journal
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- Circulation Journal
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Circulation Journal 88 (2), 182-188, 2024-01-25
The Japanese Circulation Society
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Keywords
Details 詳細情報について
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- CRID
- 1390861869684365312
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 033301169
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- PubMed
- 38092383
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
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- Abstract License Flag
- Disallowed