Shared and Reciprocal Mechanisms Between Heart Failure and Cancer ― An Emerging Concept of Heart-Cancer Axis ―
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- Kadowaki Hiroshi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Akazawa Hiroshi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Shindo Akito
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Ueda Tomomi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Ishida Junichi
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Komuro Issei
- Department of Frontier Cardiovascular Science, Graduate School of Medicine, The University of Tokyo International University of Health and Welfare
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説明
<p>Epidemiological evidence of increased risks of cancer in heart failure (HF) patients and HF in cancer patients has suggested close relationships between the pathogenesis of both diseases. Indeed, HF and cancer share common risk factors, including aging and unhealthy lifestyles, and underlying mechanisms, including activation of the sympathetic nervous system and renin-angiotensin-aldosterone system, chronic inflammation, and clonal hematopoiesis of indeterminate potential. Mechanistically, HF accelerates cancer development and progression via secreted factors, so-called cardiokines, and epigenetic remodeling of bone marrow cells into an immunosuppressive phenotype. Reciprocally, cancer promotes HF via cachexia-related wasting and metabolic remodeling in the heart, and possibly via cancer-derived extracellular vesicles influencing myocardial structure and function. The novel concept of the “heart-cancer axis” will help in our understanding of the shared and reciprocal relationships between HF and cancer, and provide innovative diagnostic and therapeutic approaches for both diseases.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 88 (2), 182-188, 2024-01-25
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390861869684365312
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 033301169
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- PubMed
- 38092383
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
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- 抄録ライセンスフラグ
- 使用不可