Drug-induced Interstitial Nephritis in a Patient with Ulcerative Colitis Treated with 5-Aminosalicylic Acid

  • Hayashi Daichi
    Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
  • Nishida Tsutomu
    Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
  • Osugi Naoto
    Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
  • Kusunoki Yasuo
    Division of Nephrology, Department of Internal Medicine, Toyonaka Municipal Hospital, Japan
  • Okabe Satoru
    Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
  • Fujii Yoshifumi
    Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
  • Nakamatsu Dai
    Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
  • Matsumoto Kengo
    Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
  • Yamamoto Masashi
    Department of Gastroenterology, Toyonaka Municipal Hospital, Japan
  • Fukui Koji
    Department of Gastroenterology, Toyonaka Municipal Hospital, Japan

抄録

<p>This report describes the case of a 76-year-old man with ulcerative colitis who developed interstitial nephritis after starting 5-Aminosalicylic acid (5-ASA) therapy. The patient experienced an initial improvement in symptoms, but developed fatigue, anorexia, and severe renal dysfunction 2.5 months later. Renal biopsy confirmed drug-induced interstitial nephritis, and conservative treatment with fluid replacement and the discontinuation of 5-ASA improved the patient's condition. Clinicians should monitor patients receiving 5-ASA therapy for potential adverse effects, particularly renal injury, and promptly investigate symptoms of renal dysfunction. Early recognition and discontinuation of the offending agent may prevent further damage and improve patient outcomes. </p>

収録刊行物

  • Internal Medicine

    Internal Medicine 63 (8), 1081-1085, 2024-04-15

    一般社団法人 日本内科学会

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