Acoustic radiation force impulse-induced lung hemorrhage: investigating the relationship with peak rarefactional pressure amplitude and mechanical index in rabbits

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  • TAKAYAMA Noriya
    Department of Clinical Laboratory Medicine, Jichi Medical University
  • SASANUMA Hideki
    Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University
  • RIFU Kazuma
    Division of Gastroenterological, General and Transplant Surgery, Department of Surgery, Jichi Medical University
  • NITTA Naotaka
    Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology(AIST)
  • AKIYAMA Iwaki
    Medical Ultrasound Research Center, Doshisha University
  • TANIGUCHI Nobuyuki
    Department of Clinical Laboratory Medicine, Jichi Medical University

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Other Title
  • 音響放射力インパルスにより引き起こされるウサギの肺出血：最大負音圧およびメカニカルインデックスとの関係についての評価

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<p>Purpose: The safety of acoustic radiation force impulse (ARFI) elastography, which applies higher acoustic power with a longer pulse duration (PD) than conventional diagnostic ultrasound, is yet to be verified. We assessed the ARFI-induced lung injury risk and its relationship with peak rarefactional pressure amplitude (PRPA) and mechanical index (MI). Methods: Eighteen and two rabbits were included in the ARFI (0.3-ms push pulses) and sham groups, respectively. A 5.2-MHz linear probe was applied to the subcostal area and aimed at both lungs through the liver for 30 ARFI emissions. The derated PRPA varied among the six ARFI groups－0.80 MPa, 1.13 MPa, 1.33 MPa, 1.70 MPa, 1.91 MPa, and 2.00 MPa, respectively. Results: The occurrence of lung hemorrhage and the mean lesion area among all samples in the seven groups were 0/6, 0/6, 1/6 (1.7 mm2), 4/6 (8.0 mm2), 4/6 (11.2 mm2), 5/6 (23.8 mm2), and 0/4 (sham), respectively. Logistic regression analysis showed that derated PRPA was significantly associated with lung injury occurrence (odds ratio: 207, p < 0.01), with the threshold estimated to be 1.1 MPa (MI, 0.5). Spearman’s rank correlation showed a positive correlation between derated PRPA and lesion area (r = 0.671, p < 0.01). Conclusion: This study demonstrated that the occurrence and severity of ARFI-induced lung hemorrhage increased with a rise in PRPA under clinical conditions in rabbits. This indicates a potential risk of lung injury due to ARFI elastography, especially when ARFI is unintentionally directed to the lungs during liver, heart, or breast examinations.</p>

Journal

  • Choonpa Igaku

    Choonpa Igaku 52 (2), 77-85, 2025

    The Japan Society of Ultrasonics in Medicine

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