Clinical research on a relationship between oral microbiota and systemic conditions of allo-HCT recipients

DOI
  • Oku Saori
    Geriatric Dentistry and Perioperative Medicine in Dentistry, Kyushu University Hospital
  • Takeshita Toru
    Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth, Development, Faculty of Dental Science, Kyushu University
  • Futatsuki Toshiko
    Hamanomachi Hospital
  • Imamura Yoshiko
    Geriatric Dentistry and Perioperative Medicine in Dentistry, Kyushu University Hospital
  • Mori Yasuo
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
  • Kashiwazaki Haruhiko
    Geriatric Dentistry and Perioperative Medicine in Dentistry, Kyushu University Hospital

Bibliographic Information

Other Title
  • 造血細胞移植患者の臨床研究―口腔微生物叢と全身状態との関わり―

Description

<p> Allogeneic hematopoietic cell transplantation (allo-HCT) recipients are highly susceptible to various infections due to the myelosuppression caused by conditioning chemoradiotherapy and the use of immunosuppressants. The oral cavity contains a diverse array and substantial number of bacteria, which can lead to infections when oral mucotitis occurs. Therefore, it is crucial to eliminate potential oral infections and improve oral hygiene before transplantation. In our hospital, we perform oral cleansing and remove sources of oral infection for patients scheduled to undergo allo-HCT. Furthermore, during the transplantation process, an oral care support team consisting of dentists and dental hygienists provides oral care support in collaboration with hematologists and nurses. In this context, we have considered the potential impact of the oral environment on transplant outcomes, including oral adverse events, and have particularly focused on the oral microbiota in our ongoing clinical research. In this report, we outline our hospital’s oral management strategies for allo-HCT recipients and present findings from our clinical research on the relationship between the oral microbiota, systemic conditions, and oral adverse events in allo-HCT recipients.</p>

Journal

Keywords

Details 詳細情報について

  • CRID
    1390866882738254080
  • DOI
    10.7889/tct-24-012
  • ISSN
    2436455X
  • Text Lang
    ja
  • Data Source
    • JaLC
  • Abstract License Flag
    Disallowed

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