Study Profile of the Iwate PGS Assessment and Risk Communication (PARC) Study
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- Yoshida Akiko
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University
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- Tokutomi Tomoharu
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University
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- Suzumori Nobuhiro
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University
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- Fukushima Akimune
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University
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- Tanno Kozo
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University
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- Sutoh Yoichi
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University Institute for Biomedical Sciences, Iwate Medical University
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- Ohmomo Hideki
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University Institute for Biomedical Sciences, Iwate Medical University
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- Hachiya Tsuyoshi
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University Institute for Biomedical Sciences, Iwate Medical University
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- Kotozaki Yuka
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University
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- Toya Yukiko
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University
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- Hasegawa Atsushi
- Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University
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- Hamanaka Yohei
- Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University
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- Nagaie Satoshi
- Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University
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- Kudo Hisaaki
- Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University
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- Ogishima Soichi
- Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University
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- Nagami Fuji
- Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University
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- Sakurai-Yageta Mika
- Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University
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- Kumada Kazuki
- Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University
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- Narita Akira
- Tohoku Medical Megabank Organization, Tohoku University
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- Otsuka-Yamasaki Yayoi
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University Institute for Biomedical Sciences, Iwate Medical University
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- Komaki Shohei
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University Institute for Biomedical Sciences, Iwate Medical University
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- Minabe Shiori
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University Institute for Biomedical Sciences, Iwate Medical University
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- Ishigaki Yasushi
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University
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- Yamamoto Masayuki
- Tohoku Medical Megabank Organization, Tohoku University Graduate School of Medicine, Tohoku University
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- Asahi Koichi
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Medicine, Iwate Medical University
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- Endo Ryujin
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University School of Nursing, Iwate Medical University
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- Shimizu Atsushi
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University Institute for Biomedical Sciences, Iwate Medical University
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- Sasaki Makoto
- Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University Institute for Biomedical Sciences, Iwate Medical University
書誌事項
- 公開日
- 2026-02-05
- 資源種別
- journal article
- DOI
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- 10.2188/jea.je20250078
- 公開者
- 日本疫学会
この論文をさがす
説明
<p>Background: The potential impacts of polygenic scores (PGS) on health-behavior changes are not fully understood. The Iwate PGS Assessment and Risk Communication Study aims to investigate the effects of reporting PGS-based risk for ischemic stroke on health behaviors.</p><p>Methods: Participants wishing to know their PGS-based ischemic stroke risk were recruited from health checkup venues for workers in Iwate Prefecture in 2023. Health checkup data, biospecimens, and questionnaire responses were collected for biochemical testing, genotyping, and storage in the Tohoku Medical Megabank integrated biobank. The risk was calculated using an integrative PGS model for East Asians. Participants were randomly assigned to two groups, and one group received their risk report as the intervention group. The impacts of the risk notification will be investigated in follow-up surveys.</p><p>Results: Of 3,599 workers, 2,088 participated in the study (consent rate: 58.0%). The demographic profile of the eligible 2,083 participants was as follows: 80.7% males, and dominance of participants aged 18–29 years (25.2%), in their 30’s (25.3%), and in their 40’s (24.7%). Two hundred participants (9.7%) had a risk of 1.0 as the reference; 57 (2.7%), 927 (44.7%), and 888 (42.9%) participants had 2.1–3.4-, 1.4–1.9-, and <1.0-fold that risk, respectively.</p><p>Conclusion: We collected health information and biospecimens from over 2,000 workers and disclosed the PGS-based ischemic stroke risk. Behavioral effects will be evaluated 1 year after disclosure, with follow-up until 2030. As Japan’s first large-scale PGS risk communication study, it will provide initial insights for implementing PGS in personalized preventive medicine.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ
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Ｊｏｕｒｎａｌ ｏｆ Ｅｐｉｄｅｍｉｏｌｏｇｙ 36 (2), 73-84, 2026-02-05
日本疫学会
