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- 宮田 佳樹
- 帝京大学薬学部
書誌事項
- タイトル別名
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- Structure Activity Relationship Study of Polymethoxylated Flavones Targeted Retinal Müller Cells for Prevention of Retinal Diseases
- モウマク ミュラー サイボウ オ ヒョウテキ ト スル モウマク シッカン ヨボウ エ ムケタ シンキ ポリメトキシフラボンルイ ノ コウゾウ カッセイ ソウカン ケンキュウ
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説明
<p>Diabetic retinopathy (DR) is a retinal disease representing one of the main causes of vision loss in developed countries. In the early stage of DR, disruption of blood retinal barrier (BRB) is observed, and it will lead to vascular permeability and visual impairment. Therefore, protection against the breakdown of BRB may be useful strategy for prevention of DR. Matrix metalloproteinases (MMPs) plays an important role in the degradation of extracellular matrix proteins. In DR, they attribute to increased vascular permeability by degrading the junction proteins, such as occuldin and cadherin that are important to maintain the BRB junction complex. Müller cells constitute the main glial cells of the retina and are involved in many retinal functions. They are reported to be one of the MMP-producing cells in the retina. In this symposium review, I present the molecular mechanism of MMP expression in retinal Müller cells. In addition, I would like to introduce polymethoxylated flavones, nobiletin and the derivatives isolated from natural resource as novel MMP inhibitors, which may be applicable to prevention of DR.</p>
収録刊行物
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- 薬学雑誌
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薬学雑誌 141 (1), 41-45, 2021-01-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1391131406295016320
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- NII論文ID
- 130007964823
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 031230179
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- PubMed
- 33390446
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可