A planarian orthopedia homolog is specifically expressed in the branch region of both the mature and regenerating brain

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  • planarian orthopedia homolog is specifi

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<jats:p>To analyze the organization of planarian brain, a homolog of the homeobox‐containing gene <jats:italic>Orthopedia (Otp)</jats:italic> from planarian, <jats:italic>Djotp</jats:italic>, was isolated. The homeodomain of <jats:italic>Djotp</jats:italic> differs from mouse <jats:italic>Otp</jats:italic> by only two amino acids. This conservation extends to include a 12 amino acid motif downstream of the homeodomain. Whole mount <jats:italic>in situ</jats:italic> hybridization studies indicated that <jats:italic>Djotp</jats:italic> is specifically expressed in the branch structures of the normal planarian adult brain. During regeneration, <jats:italic>Djotp</jats:italic> is expressed in the presumptive branch region prior to branch formation. These observations implicate a role for <jats:italic>Djotp</jats:italic> in establishing and maintaining the identity of the planarian brain branch region. The results suggest that recruitment of <jats:italic>Otp</jats:italic> for its role in brain pattern formation occurred very early in evolution.</jats:p>

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