Clomiphene-HMG Ovarian Stimulation in Human in Vitro Fertilization and Embryo Transfer

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  • ODA,Takahisa
    Department of Obstetrics and Gynecology, Tokyo Dental College, Ichikawa Hosptal
  • YOSHIMURA,Sinichi
    Department of Obstetrics and Gynecology, Tokyo Dental College, Ichikawa Hosptal
  • SUMI,Yukari
    Department of Obstetrics and Gynecology, Tokyo Dental College, Ichikawa Hosptal
  • SIINA,Masaki
    Department of Obstetrics and Gynecology, Tokyo Dental College, Ichikawa Hosptal
  • YAHAGI,Miki
    Department of Obstetrics and Gynecology, Tokyo Dental College, Ichikawa Hosptal
  • MATSUMOTO,Chiaki
    Department of Obstetrics and Gynecology, Tokyo Dental College, Ichikawa Hosptal
  • OHNO,Toranoshin
    Department of Obstetrics and Gynecology, Tokyo Dental College, Ichikawa Hosptal
  • HARA,Sumiko
    Department of Obstetrics and Gynecology, Keio University School of Medicine
  • NAKAMURA,Yukio
    Department of Obstetrics and Gynecology, Keio University School of Medicine
  • IIZUKA,Rihachi
    Department of Obstetrics and Gynecology, Keio University School of Medicine

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Other Title
  • Clomiphene-HMG卵巣刺激法による体外受精・胚移植法の検討

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Abstract

In a program for in vitro fertilization and embryo transfer, laparoscopies for oocyte aspiration were performed in 40 cycles in 36 normally menstruating women with irreparable tubal diseases (IVF patients) who received clomiphene citrate (CO) and human menopausal gonadotropin (hMG). An intramuscular injection of human chorionic gonadotropin (hCG) was given to all patients after completion of follicular maturation. Fourteen cycles in 13 spontaneously ovulating women (control patients), also stimulated with CC and hMG, were adequately monitored to identify the appearance of the spontaneous luteinizing hormone (LH) surge. The follicular maturation was followed by daily ovarian ultrasonographic examination and serum estradiol estimations. Just before the LH surge the diameter of the leading follicle was 20.2±0.7 (mean ± S.E.) mm and the serum estradiol concentration per follicle was 384.1±16.3pg/ml in the control patients. In the IVF patients the former was 20.6±0.3mm and the latter was 305.8±13.3pg/ml prior to hCG administration. When the relationship of follicular size to the rates of oocytes recovery, maturation, fertilization and cleavage was examined, larger follicles (3ml≦follicular fluid volume) showed good results. Of the 152 oocytes that were recovered from these IVF patients, 96 (63.2%) were fertilized and 79 (52.0%) cleaved. Three pregnancies resulted from 35 embryo transfers.

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