Microbiological Production of 20-Carboxy-Pregna-1,4-Dien-3-One from β-Sitosterol with High Yield by a Rhodococcus Species : Studies on Microbial Transformations (XXII) :

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  • IIDA,MITSUGI
    Department of Applied Biological Science, Science University of Tokyo
  • MUROHISA,TOMOO
    Department of Applied Biological Science, Science University of Tokyo
  • YONEYAMA,ATSUKO
    Department of Applied Biological Science, Science University of Tokyo
  • IIZUKA,HIROSHI
    Department of Applied Biological Science, Science University of Tokyo

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Description

Among nine soil isolates able to decompose β-sitosterol, Rhodococcus sp. MIL 1037 produced 20-carboxy-pregna-1,4-dien-3-one (BNC) in high yield of 56% from β-sitosterol in the presence of 1×10^<-3> M α, α'-dipyridyl. In addition, 20-carboxy-pregn-4-en-3-one (4BNC) (7% yield), androsta-1,4-dien-3-one (ADD) (9%) and androst-4-en-3-one (4AD) (1%) were obtained as minor products of the cleavage of the β-sitosterol side-chain. These products were characterized by a variety of conventional chemical and spectrometric techniques.

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