Biopharmaceutical Studies of Thiazide Diuretics. III. : In Vivo Formation of 2-Amino-4-chloro-m-benzenedisulfonamide as a Metabolite of Hydrochlorothiazide in a Patient(Pharmaceutical)

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Urine, plasma and erythrocytes from a patient receiving hydrochlorothiazide were examined by high-performance liquid chromatography. The urine and erythrocyte showed an unknown peak in the chromatograms. This substance was identified as 2-amino-4-chloro-m-benzenedisulfonamide and the identification was confirmed by comparison of the substance with an authentic sample obtained by synthesis. All data were analyzed with a PC 9801VM computer in conjunction with a JASCO MULTI-320 multi-wavelength ultraviolet detector.

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