ローラポンプの繰り返し負荷による流路形状変化が血流特性に及ぼす影響の検討

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  • Evaluation of the Effects of the Changes in Flow Channel Deformation by Cyclic Loading on Blood Flow Characteristics in a Roller Pump Model
  • ローラポンプ ノ クリカエシ フカ ニ ヨル リュウロ ケイジョウ ヘンカ ガ ケツリュウ トクセイ ニ オヨボス エイキョウ ノ ケントウ

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<p>Roller pumps are widely used as one of the cardiopulmonary bypasses during open-heart surgery. Hemolysis may cause acute kidney injury due to the changes in the tubing gap by the occlusion of roller pumps. In this study, we achieved the 3-D evaluation of the roller pump tubing gap for the first time by our originally developed visualization analysis. We examined the leak rate and the hemolysis under the 240-min circulatory support condition in a mock flow tester, and compared the tubing gap dimensions. As a result, the primary leak rate around 0.8 mL/min against 1 mH2O afterload significantly decreased after 60-min circulation, and there was no leak rate detected for 10 minutes measurement afterwards. The 3-D tubing gaps indicated that the subsidiary opening width at the short-axis edge decreased by more flattening shapes. Moreover, plasma free hemoglobin levels showed a remarkable increase at 60-min after the pump start, although there was no discernible difference in the incremental ratio of hemolysis following 240-min support. Therefore, our findings suggest that the leak rate and hemolysis are to be considered by the primary occlusion settings as well as the time-varying gap deformation for longer use of roller pumps.</p>

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