Studies on Gas Exchange and Acid-base Balance in the Tissue by Means of the Subcutaneous Liquid Pocket with Fluorocarbon Emulsion

  • KODAKA Yasuko
    Department of Physiology, School of Medicine, Tokai University
  • OHTA Yasuyo
    Department of Physiology, School of Medicine, Tokai University

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Description

A subcutaneous liquid pocket with fluorocarbon emulsion has been used as a new means to assess acid-base balance and gas exchange in the tissue. The pocket contents of rats under ambient air breathing showed a pO_2 of 45.8±3.3 Torr, pCO_2 of 49.0±1.3 Torr, pH of 7.374±0.052 and HCO^-_3 of 17.1±2.2 mEq/L. Changes in the above parameters were studied under hypoxic, hypercapneic and asphyxic environments and comparied in part with those in arterial blood. Respiratory alkalosis under hypoxia and respiratory acidosis with some improvement in oxygenation in the tissues were observed. Acetazolamide given intraperitoneally under asphyxic conditions not only induced metabolic acidosis, but also caused a deterioration in tissue hypoxia, which may limit the therapeutic use of acetazolamide in respiratory acidosis.

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Details 詳細情報について

  • CRID
    1570572701995700608
  • NII Article ID
    110004690415
  • NII Book ID
    AA00863975
  • ISSN
    03850005
  • Text Lang
    en
  • Data Source
    • CiNii Articles

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