Studies on Gas Exchange and Acid-base Balance in the Tissue by Means of the Subcutaneous Liquid Pocket with Fluorocarbon Emulsion
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- KODAKA Yasuko
- Department of Physiology, School of Medicine, Tokai University
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- OHTA Yasuyo
- Department of Physiology, School of Medicine, Tokai University
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説明
A subcutaneous liquid pocket with fluorocarbon emulsion has been used as a new means to assess acid-base balance and gas exchange in the tissue. The pocket contents of rats under ambient air breathing showed a pO_2 of 45.8±3.3 Torr, pCO_2 of 49.0±1.3 Torr, pH of 7.374±0.052 and HCO^-_3 of 17.1±2.2 mEq/L. Changes in the above parameters were studied under hypoxic, hypercapneic and asphyxic environments and comparied in part with those in arterial blood. Respiratory alkalosis under hypoxia and respiratory acidosis with some improvement in oxygenation in the tissues were observed. Acetazolamide given intraperitoneally under asphyxic conditions not only induced metabolic acidosis, but also caused a deterioration in tissue hypoxia, which may limit the therapeutic use of acetazolamide in respiratory acidosis.
収録刊行物
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- Tokai journal of experimental and clinical medicine
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Tokai journal of experimental and clinical medicine 2 (1), 41-51, 1977-01
東海大学
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詳細情報 詳細情報について
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- CRID
- 1570572701995700608
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- NII論文ID
- 110004690415
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- NII書誌ID
- AA00863975
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- ISSN
- 03850005
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles