Modifying Effects of Maharishi Amrit Kalash 4 and 5 on Phagocytic and Digestive Functions of Macrophages in Male ICR Mice

SUGIURA Haruo, INABA Ryoichi, IWATA Hirotoshi, NISHIDA Hiroyuki, TANAKA Takuji, Department of Health and Physical Education Gifu Pharmaceutical University:Department of Hygiene Gifu University School of Medicine, Department of Hygiene Gifu Univeristy School of Medicine, Department of Hygiene Gifu University School of Medicine, Department of Health and Physical Education Gifu Pharmaceutical University, First Department of Pathology Gifu University School of Medicine

A study was carried out to examine modifying effects of Maharishi Amrit Kalash 4 (MAK 4) and Maharishi Amrit Kalashi 5 (MAK 5) on phagocytic and digestive functions of macrophages in male ICR mice. Mice at 4 week of age were divided into 3 groups : no treatment group (control), MAK 4 treated group (MAK 4 group) and MAK 5 treated group (MAK 5 group). MAK 4 and MAK 5 were given p.o. at 50 mg/kg per day (5 days/week) for 7 weeks. Phagocytic function of reticuloendothelial system evaluated by the carbon clearance was enhanced by the treatment of MAK 4 and MAK 5. Superoxide anion (O_<2->) production of peritoneal macrophages increased significantly in both MAK 4 and MAK 5 groups. The acid phosphatase activity of peritoneal macrophages increased significantly in MAK 4 group compared to the control group, but not in MAK 5 group. The activities of β-glucuronidase and lactate dehydrogenase in both MAK 4 and MAK 5 groups increased significantly when compared to the control group. These results suggest that MAK 4 and MAK 5 promote the phagocytic and digestive functions of macrophages and have a stimulatory effect on macrophages.

Modifying Effects of Maharishi Amrit Kalash 4 and 5 on Phagocytic and Digestive Functions of Macrophages in Male ICR Mice

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