Association between Bone Mineral Density and Atherosclerosis in Postmenopausal Women

  • Sato Ryoko
    Cardiovascular Medicine, Kanazawa Medical University

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  • 閉経後女性における動脈硬化と骨密度との関係

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The focus of the present study was to examine the potential link between vascular atherosclerosis and bone metabolism, both of which develop rapidly after menopause. We studied consecutive 102 postmenopausal women receiving elective coronary angiography with multi-slice computed tomography to quantify coronary calcification (CS), with ultrasonography to assess carotid plaque, and with DXA scanner to measure bone mineral density (BMD). Each of the coronary narrowing sites according to the classification of American Heart Association Grading Committee (15 segments) was scored as 1 (<25%), 2 (25-50%), 3 (50-75%) and 4 (>=75%). CAG score was defined as the sum of these scores. Each carotid plaque was scored as 1 (soft), 2 (mixed), and 3 (hard) according to image intensity, and plaque score (PS) was defined as the sum of the score multiplied by total plaque number. No subjects received hormone replacement, or had an associated condition influencing bone metabolism. CS (logtransformed), CAG score and PS values in 33 patients with significant coronary narrowing (<50% stenosis) (Patient group) were significantly higher than in 69 subjects without lesions (Control group), respectively Weight-adjusted forearm and hip BMDs were significantly, lower in Patient group relative to Control group (p=0.006, p=0.018, p<0.0001, p<0.0001). These BMDs showed significant and negative associations with CAG score (r=0.351, p=0.0003 ), CS (r=0.295, p=0.026), PT(r=0.165, p=0.0984) and PS (r=0.217, p=0.0285), and two of 4 relations were independent from traditional coronary risk factors. Our results suggest that bone mineral density in postmenopausal women is independently associated with carotid and coronary atherosclerosis.

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