Synthesis of Some Polyhydroxylated Pyrrolidine Derivatives(Organic,Chemical)

  • SETOI HIROYUKI
    Exploratory Research Laboratories, Fujisativa Pharmaceutical Co., Ltd.
  • KAYAKIRI HIROSHI
    Exploratory Research Laboratories, Fujisativa Pharmaceutical Co., Ltd.
  • TAKENO HIDEKAZU
    Exploratory Research Laboratories, Fujisativa Pharmaceutical Co., Ltd.
  • HASHIMOTO MASASHI
    Exploratory Research Laboratories, Fujisativa Pharmaceutical Co., Ltd.

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Description

Polyhydroxylated pyrrolidine derivatives, 7, 11, 15, and 18, were synthesized from 4, a. key intermediate for our total synthesis of swainsonine (1). The immunostimulating activities of these new derivatives were found to be moderate and less than that of swainsonine.

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