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SYNTHESIS OF SAFRAMYCINS. I. TOTAL SYNTHESIS OF (±)-SAFRAMYCIN B AND ITS CONGENERS.(Communication to the Editor)
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- Kubo Akinori
- Meiji College of Pharmacy
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- Saito Naoki
- Meiji College of Pharmacy
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- Yamauchi Reiko
- Meiji College of Pharmacy
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- Sakai Shin-ichiro
- Faculty of Pharmaceutical Sciences, Chiba University
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Description
We describe the total synthesis of the dimeric isoquinolinequinone antibiotic saframycin B (1) from tricyclic lactam 3. The key step is the stereoselective intramolecular cyclization of the aminoacetal 6. The structure of the pentacyclic intermediate 8 was confirmed by X-ray crystallography.
Journal
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 35 (5), 2158-2161, 1987-05-25
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1570572702349230976
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- NII Article ID
- 110006281182
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- NII Book ID
- AA00602100
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- ISSN
- 00092363
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- Text Lang
- en
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- Data Source
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- CiNii Articles