SYNTHESIS OF SAFRAMYCINS. I. TOTAL SYNTHESIS OF (±)-SAFRAMYCIN B AND ITS CONGENERS.(Communication to the Editor)

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We describe the total synthesis of the dimeric isoquinolinequinone antibiotic saframycin B (1) from tricyclic lactam 3. The key step is the stereoselective intramolecular cyclization of the aminoacetal 6. The structure of the pentacyclic intermediate 8 was confirmed by X-ray crystallography.

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