Simulation Study on Dynamics of Hippocampal CA1 Pyramidal Neuron

  • IWASAKI M.
    Graduate School of Information Sciences, Tohoku University
  • KATAYAMA N.
    Graduate School of Information Sciences, Tohoku University
  • NAKAO M.
    Graduate School of Information Sciences, Tohoku University
  • YAMAMOTO M.
    Graduate School of Information Sciences, Tohoku University

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  • 海馬錐体ニューロンダイナミクスのシミュレーション

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Recent neurophysiological studies revealed that dendrites have various voltage-gated ion channels and therefore show active properties such as action potential generation. In order to understand its functional significance, we carried out computer simulations, using a compartment neuron model. Results:(1)An inhibitory synaptic inputs call spatially modify the spike initiation and its propagation.(2)Amplitude damping phenomena of repetitively firing spikes call be reproduced by including Ca^<2+> current and Ca^<2+> dependent K.^+ current in the model.

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