Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N',N'-dimethyl-N-nitrosourea(Biological)

  • 幸田 光復
    Faculty of Pharmaceutical Sciences, Nagoya City University
  • 羽倉 昌志
    Faculty of Pharmaceutical Sciences, Nagoya City University
  • 二宮 眞一
    Faculty of Pharmaceutical Sciences, Nagoya City University
  • 川添 豊
    Faculty of Pharmaceutical Sciences, Nagoya City University

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N-Butyl-N',N'-dimethyl-N-nitrosourea (DM-BNU), the spontaneous (hydrolytic) activation rate of which is 4×10^<-4> times that of N-butyl-N-nitrosourea (BNU), is metabolized to N-butyl-N'-methyl-N-nitrosourea (MM-BNU) in the presence of S9 mix. It is, therefore, suggested that the carcinogenicity of DM-BNU, which is as potent as that of BNU, may be attributed partly to the demethylated MM-BNU, which is more readily activated to a carcinogenic reactant. This hypothesis is supported by the mutagenicilies of these carcinogens in E. coli in the presence and absence of S9 mix.

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